Indications / Uses

Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer. Buy Anazole Tablets online

First-line treatment of postmenopausal women with hormone receptor positive or hormone receptor unknown locally advanced or metastatic breast cancer.

Treatment of advanced breast cancer in postmenopausal women with disease progression after tamoxifen therapy.

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Dosage / Direction for Use

Recommended Dose: Orally 1 tablet once daily.

The optimal duration of therapy is unknown for adjuvant treatment of early breast cancer.

For treatment of advanced breast cancer, anastrozole therapy should be continued until tumor progression is evident.

Contraindications

Hypersensitivity to anastrozole or any component in the product.
Premenopausal women.
Patients with severe kidney failure.
Patients with moderate to severe liver failure.
Pregnant or breastfeeding women. Buy Anazole Tablets online
Concomitant use of: Selective estrogen receptor modulators (e.g., tamoxifen, raloxifene); Other aromatase inhibitors (e.g., exemestrane, formestane, letrozole). Not recommended for use in children

Special Precautions

Anastrozole should only be given under the supervision of a physician experienced in the use of anticancer drugs. Pregnancy should be ruled out before initiating anastrozole therapy.

Postmenopausal women receiving anastrozole are at high risk for osteoporosis.

Anastrozole has been reported to cause a reduction in bone mineral density (BMD) due to lowering of circulating estrogen concentrations.

Lifestyle changes such as weight-bearing exercise and dietary supplementation with calcium and vitamin D are advised to reduce the risk of osteoporosis in women taking anastrozole as adjuvant therapy. Buy Anazole Tablets online

Monitor serum lipoprotein concentrations in patients receiving long-term anastrozole therapy.
Effects on Ability to Drive or Use Machines: Anastrozole is unlikely to impair the ability of patients to drive or operate machinery.

However, asthenia and somnolence have been reported with the use of anastrozole. Caution should be observed when driving or operating machinery.

Hepatic and renal impairment: Dosage adjustment is not required in patients with mild to moderate renal and hepatic impairment.

patients with hepatic disease resulting in severe hepatic impairment should be carefully monitored for adverse effects since almost 85% of anastrozole elimination occurs in the liver.

Use in Children: Safety and effectiveness of anastrozole in pediatric patients younger than 18 years old has not been established.

Anastrozole is not recommended for use in children.

Use in Elderly: No dosage adjustment is necessary in elderly patients receiving anastrozole. There is no reported evidence of altered pharmacokinetics in women older than 80 years old.

Adverse Reactions

Cardiovascular Effects: Ischemic cerebrovascular events and ischemic cardiovascular disease, angina pectoris and myocardial infarction have been reported with anastrozole use as adjuvant therapy.

Other effects may include hot flushes, increased serum cholesterol, vasodilation, hypertension, lymphedema, hypertension, and peripheral edema.

Genitourinary Effects: Adjuvant therapy with anastrozole may cause vaginal bleeding, vaginal discharge and vulvovaginitis. Endometrial cancer was also reported.

First-line or second-line therapy with anastrozole may cause adverse effects such as pelvic pain, vaginal bleeding and vaginal dryness.

Musculoskeletal Effects: Patients receiving anastrozole are at high risk for osteoporosis since the drug may cause a reduction in bone mineral density.

Other effects may include bone pain, myalgia, pathologic fracture, back pain, and neck pain. Hands, knees, hips, lower back, or shoulders may experience joint pains.

Stiffness, particularly in the morning has also been reported.

Gastrointestinal Effects: Nausea and vomiting; dyspepsia, diarrhea, abdominal pain, constipation, and anorexia and unspecified GI disorder.

Respiratory Effects: Pharyngitis, dyspnea, sinusitis, bronchitis, rhinitis, and increased cough.
CNS Effects: CNS effects have been reported including mood disturbance, depression, insomnia, anxiety, headache, dizziness, paresthesia, somnolence, confusion, nervousness, and hypertonia.

Dermatologic Effects: Rash, sweating, hair thinning and pruritus have been reported with anastrozole therapy.

Hepatic Effects: Increased serum concentrations of γ-glutamyltransferase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase were reported.

Hematologic Effects: Anemia and leukopenia.

Sensitivity Reactions: Rare reports of systemic allergic reactions including angioedema, urticaria, and anaphylaxis in patients receiving anastrozole.

Others: Weight loss, weight gain, cataracts, asthenia, nonspecific pain, chest pain (nonspecific), flu syndrome, accidental injury, lethargy, fever, and malaise.

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Interactions

Concomitant use with estrogens may diminish the action of anastrozole.
Anastrozole may inhibit the in vitro metabolic reactions catalyzed by cytochrome P-450 isoenzymes 1A2, 2C8/9, and 3A4 but only at high concentrations. http://rxonline-pharmacy.us/product/anazole-for-sale/

Common Names

Aridex, Qubol, Armotraz, Anabrez, Femitraz, Redest, Anatero, Femistra, Armilon, PMBC, Altrol, Anastrozole Tablets, Arimidex, Arimixyl, Anastrozolos, Stazonex, Anastrocare, Altraz.

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